*Doses are commonly-reported figures from public sources, not a recommendation. Educational only.
| Year | Title / venue | Source |
|---|---|---|
| 2025 | Kisspeptin and neurokinin B: roles in reproductive health Physiological reviews · preclinical | PMID 39813600 |
| 2024 | Kisspeptin and mammalian reproduction Peptides · preclinical | PMID 39306000 |
| 2024 | Kisspeptin signaling in astrocytes modulates the reproductive axis The Journal of clinical investigation · preclinical | PMID 38861336 |
| 2024 | Kisspeptin and neurokinin B neuroendocrine pathways in the control of human ovulation Journal of neuroendocrinology · preclinical | PMID 38404024 |
| 2022 | Stress, kisspeptin, and functional hypothalamic amenorrhea Current opinion in pharmacology · preclinical | PMID 36103784 |
| 2022 | The Role of Kisspeptin in the Control of the Hypothalamic-Pituitary-Gonadal Axis and Reproduction Frontiers in endocrinology · preclinical | PMID 35837314 |
| 2022 | Hypothalamic kisspeptin and kisspeptin receptors: Species variation in reproduction and reproductive behaviours Frontiers in neuroendocrinology · preclinical | PMID 34757093 |
| 2020 | Metabolic regulation of kisspeptin - the link between energy balance and reproduction Nature reviews. Endocrinology · preclinical | PMID 32427949 |
| 2020 | Kisspeptin and GnRH interactions in the reproductive brain of teleosts General and comparative endocrinology · preclinical | PMID 32710898 |
| 2020 | Role of Kisspeptin in Regulation of Reproductive and Immune Reactions Biochemistry. Biokhimiia · preclinical | PMID 33045946 |
| 2019 | Kisspeptin and Glucose Homeostasis Seminars in reproductive medicine · preclinical | PMID 31869842 |
| 2018 | The hypothalamus-pituitary-gonad axis: Tales of mice and men Metabolism: clinical and experimental · preclinical | PMID 29223677 |
| 2018 | KNDy Cells Revisited Endocrinology · preclinical | PMID 30010844 |
| 2018 | Kisspeptin and the control of emotions, mood and reproductive behaviour The Journal of endocrinology · preclinical | PMID 30306845 |
| 2016 | Kisspeptin across the human lifespan:evidence from animal studies and beyond The Journal of endocrinology · preclinical | PMID 27340201 |
| 2014 | The kisspeptin-GnRH pathway in human reproductive health and disease Human reproduction update · preclinical | PMID 24615662 |
| 2013 | Kisspeptin antagonists Advances in experimental medicine and biology · preclinical | PMID 23550006 |
| 2008 | GPR54 and kisspeptins Results and problems in cell differentiation · preclinical | PMID 18193176 |
| 2007 | Kisspeptin in reproduction Seminars in reproductive medicine · preclinical | PMID 17710729 |
| 2007 | Leptin in reproduction Current opinion in endocrinology, diabetes, and obesity · preclinical | PMID 17982352 |
Kisspeptin (Kisspeptin (Kisspeptin-10 / metastin)). Hypothalamic peptide that stimulates GnRH release via the KISS1R receptor — a master regulator of the reproductive axis (LH/FSH).
Commonly discussed uses: reproductive-endocrine research, investigational: hypogonadism, IVF triggering, sexual-brain processing studies. There is both human and animal/preclinical research, though the depth and quality vary by indication. Note: most uses are not approved indications.
Mechanism: Hypothalamic peptide that stimulates GnRH release via the KISS1R receptor — a master regulator of the reproductive axis (LH/FSH).
Reported considerations: generally well tolerated in trials at studied doses. There is both human and animal/preclinical research, though the depth and quality vary by indication. Investigational. Not approved. Active clinical-research interest in fertility medicine. This is not a safety endorsement; safety data for unapproved compounds is incomplete.
Commonly cited ranges (educational reference, not a recommendation): low research/trial-defined, typical investigational (bolus/infusion in studies), high trial-defined. Administration: subcutaneous, intravenous (trials). Half-life: very short (minutes for KP-10).
Australian status: Investigational — not approved. Investigational. Not approved. Active clinical-research interest in fertility medicine. General regulatory context: most active peptides are Schedule 4 and require a prescription; import via the Personal Importation Scheme requires a valid Australian prescription for prescription-only goods.
Reconstitution/storage reference: research/trial-defined; storage: refrigerated/frozen.
Commonly discussed combinations (anecdotal for unapproved compounds): investigational; clinical-research use only. Stacking increases interaction/safety uncertainty.